Academic Papers

Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer

Hsien-Yeh Hsu,a,1,2,3,* Tung-Yi Lin,1,2,* Mei-Kuang Lu,4,5 Pei-Ju Leng,1 Shu-Ming Tsao,1 and Yu-Chung Wu6,7

Fucoidan Exerts Anticancer Effects Against Head and Neck Squamous Cell Carcinoma In Vitro

Wiktoria Blaszczak, Michal Stefan Lach, Wojciech Barczak, Wiktoria Maria Suchorska Molecules. 2018 Dec; 23(12): 3302. Published online 2018 Dec 12. doi: 10.3390/molecules23123302 PMCID: PMC6321539

Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

Geert van Weelden, Marcin Bobiński, Karolina Okła, Willem Jan van Weelden, Andrea Romano, Johanna M. A. Pijnenborg Mar Drugs. 2019 Jan; 17(1): 32. Published online 2019 Jan 7. doi: 10.3390/md17010032 PMCID: PMC6356449

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

Hye-Jin Boo, Ji-Young Hong, Sang-Cheol Kim, Jung-Il Kang, Min-Kyoung Kim, Eun-Ji Kim, Jin-Won Hyun, Young-Sang Koh, Eun-Sook Yoo, Jung-Mi Kwon, Hee-Kyoung Kang Mar Drugs. 2013 Aug; 11(8): 2982–2999. Published online 2013 Aug 19. doi: 10.3390/md11082982 PMCID: PMC3766877

Epigenetic Modification and Differentiation Induction of Malignant Glioma Cells by Oligo-Fucoidan

Chien-Huang Liao, I-Chun Lai, Hui-Ching Kuo, Shuang-En Chuang, Hsin-Lun Lee, Jacqueline Whang-Peng, Chih-Jung Yao, Gi-Ming Lai Mar Drugs. 2019 Sep; 17(9): 525. Published online 2019 Sep 8. doi: 10.3390/md17090525 PMCID: PMC6780514

Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway

Cheng-Hsien Chen, Yuh-Mou Sue, Chung-Yi Cheng, Yen-Cheng Chen, Chung-Te Liu, Yung-Ho Hsu, Pai-An Hwang, Nai-Jen Huang, Tso-Hsiao Chen Sci Rep. 2017; 7: 40183. Published online 2017 Jan 18. doi: 10.1038/srep40183 PMCID: PMC5241801

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Hsien-Yeh Hsu, Pai-An Hwang Clin Transl Med. 2019; 8: 15. Published online 2019 May 1. doi: 10.1186/s40169-019-0234-9 PMCID: PMC6491526

Fucoidan inhibits Ca2+ responses induced by a wide spectrum of agonists for G-protein-coupled receptors

Hong Wu, Shuibo Gao, Min Fu, Takashi Sakurai, Susumu Terakawa Mol Med Rep. 2018 Jan; 17(1): 1428–1436. Published online 2017 Nov 13. doi: 10.3892/mmr.2017.8035 PMCID: PMC5780082

Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells

In-Hye Kim, Mi-Jin Kwon, Taek-Jeong Nam Mol Med Rep. 2017 Jun; 15(6): 4116–4122. Published online 2017 Apr 27. doi: 10.3892/mmr.2017.6520 PMCID: PMC5436236

Selective Suppression of Cell Growth and Programmed Cell Death-Ligand 1 Expression in HT1080 Fibrosarcoma Cells by Low Molecular Weight Fucoidan Extract

Kiichiro Teruya, Yoshihiro Kusumoto, Hiroshi Eto, Noboru Nakamichi, Sanetaka Shirahata Mar Drugs. 2019 Jul; 17(7): 421. Published online 2019 Jul 19. doi: 10.3390/md17070421 PMCID: PMC6669552

Characterization and Immunomodulatory Effects of High Molecular Weight Fucoidan Fraction from the Sporophyll of Undaria pinnatifida in Cyclophosphamide-Induced Immunosuppressed Mice

Hee Joon Yoo, Dong-Ju You, Kwang-Won Lee Mar Drugs. 2019 Aug; 17(8): 447. Published online 2019 Jul 29. doi: 10.3390/md17080447 PMCID: PMC6723532

Fucoidan Inhibits the Proliferation of Human Urinary Bladder Cancer T24 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis

Hye Young Park, Gi-Young Kim, Sung-Kwon Moon, Wun Jae Kim, Young Hyun Yoo, Yung Hyun Choi Molecules. 2014 May; 19(5): 5981–5998. Published online 2014 May 9. doi: 10.3390/molecules19055981

Anticancer Effect of Fucoidan on DU-145 Prostate Cancer Cells through Inhibition of PI3K/Akt and MAPK Pathway Expression

Gang-Sik Choo, Hae-Nim Lee, Seong-Ah Shin, Hyeong-Jin Kim, Ji-Youn Jung Mar Drugs. 2016 Jul; 14(7): 126. Published online 2016 Jul 7. doi: 10.3390/md14070126

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

Tse-Hung Huang, Yi-Han Chiu, Yi-Lin Chan, Ya-Huang Chiu, Hang Wang, Kuo-Chin Huang, Tsung-Lin Li, Kuang-Hung Hsu, Chang-Jer Wu Mar Drugs. 2015 Apr; 13(4): 1882–1900. Published online 2015 Apr 3. doi: 10.3390/md13041882

Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation

Pai-An Hwang, Hong-Ting Victor Lin, Hsin-Yuan Lin, Szu-Kuan Lo Mar Drugs. 2019 Mar; 17(3): 175. Published online 2019 Mar 18. doi: 10.3390/md17030175

Fucoidan Exerts Anticancer Effects Against Head and Neck Squamous Cell Carcinoma In Vitro

Wiktoria Blaszczak, Michal Stefan Lach, Wojciech Barczak, Wiktoria Maria Suchorska Molecules. 2018 Dec; 23(12): 3302. Published online 2018 Dec 12. doi: 10.3390/molecules23123302

Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo

Farzaneh Atashrazm, Ray M. Lowenthal, Joanne L. Dickinson, Adele F. Holloway, Gregory M. Woods Oncotarget. 2016 Jul 19; 7(29): 46028–46041. Published online 2016 Jun 14. doi: 10.18632/oncotarget.10016

Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades

Shaohua Chen, Yang Zhao, Yu Zhang, Daohai Zhang PLoS One. 2014; 9(9): e108157. Published online 2014 Sep 18. doi: 10.1371/journal.pone.0108157

Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression

Li-Mei Chen, Po-Yen Liu, Yen-An Chen, Hong-Yu Tseng, Pei-Chun Shen, Pai-An Hwang, Hsin-Ling Hsu Sci Rep. 2017; 7: 11864. Published online 2017 Sep 19. doi: 10.1038/s41598-017-12111-1

Fucoidan Extracted from the New Zealand Undaria pinnatifida—Physicochemical Comparison against Five Other Fucoidans: Unique Low Molecular Weight Fraction Bioactivity in Breast Cancer Cell Lines

Jun Lu, Keyu Kally Shi, Shuping Chen, Junqiao Wang, Amira Hassouna, Loretta Nicole White, Fabrice Merien, Mingyong Xie, Qingjun Kong, Jinyao Li, Tianlei Ying, William Lindsey White, Shaoping Nie Mar Drugs. 2018 Dec; 16(12): 461. Published online 2018 Nov 22. doi: 10.3390/md16120461

Fucoidan as a Marine Anticancer Agent in Preclinical Development

Jong-Young Kwak Mar Drugs. 2014 Feb; 12(2): 851–870. Published online 2014 Jan 28. doi: 10.3390/md12020851

Fucoidan inhibition of lung cancer in vivo and in vitro: role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation

Hsien-Yeh Hsu, Tung-Yi Lin, Yu-Chung Wu, Shu-Ming Tsao, Pai-An Hwang, Yu-Wei Shih, Jason Hsu Oncotarget. 2014 Sep; 5(17): 7870–7885. Published online 2014 Aug 6. doi: 10.18632/oncotarget.2317

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

Farzaneh Atashrazm, Ray M. Lowenthal, Gregory M. Woods, Adele F. Holloway, Joanne L. Dickinson Mar Drugs. 2015 Apr; 13(4): 2327–2346. Published online 2015 Apr 14. doi: 10.3390/md13042327

Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

Geert van Weelden, Marcin Bobiński, Karolina Okła, Willem Jan van Weelden, Andrea Romano, Johanna M. A. Pijnenborg Mar Drugs. 2019 Jan; 17(1): 32. PublishFucoidan Structure and Activity in Relation to Anti-Cancer Mechanismsed online 2019 Jan 7. doi: 10.3390/md17010032

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